The CHANG™ You Trust Is Back.

Same trusted formulations. Expanded support from Nexpring Health. Renewed confidence for your lab.

Irvine Scientific CHANG™ Cytogenetics Media is now part of Nexpring Health, bringing you the same trusted formulations for prenatal and oncology cytogenetics, now backed by expanded service, expertise, and global resources.   

Cytogenetic laboratories operate in demanding environments where cell culture performance is essential for accurate chromosome analysis and confident clinical reporting.

CHANG™ media solutions are designed to support the performance characteristics cytogenetics laboratories rely on, including reliable mitotic indices, high‑quality chromosome morphology, and clear, reproducible banding patterns across diverse sample types used in prenatal, oncology, and constitutional testing for both clinical diagnostics and research.

Reliable cell growth

Optimal chromosome morphology

High-quality metaphase spreads

A Trusted Partner for Cytogenetic Laboratories.
Built on Quality, Service, Trust, and Progress

Partnership beyond products with workflow specific support, lot reserves, and dependable follow-through.

Rigorous manufacturing and quality control systems ensure reliable, reproducible performance, and lot-to-lot consistency.

Built on decades of proven consistency, our unchanged formulations are trusted and preferred by laboratories worldwide.

Continuous innovation focused on improving laboratory workflows and supporting the evolving needs of modern cytogenetics.

CHANG Amnio

Prenatal Cytogenetics

Culture media solutions for the growth and chromosome analysis of prenatal specimens, including amniotic fluid samples, chorionic villus sampling (CVS), and products of conception tissues (POC) for clinical diagnostic applications.

CHANG Marrow

Cancer Cytogenetics

Cell culture solutions are designed to support cell differentiation and chromosome analysis in hematologic specimens, such as bone marrow, leukemic peripheral blood, and solid tumors, for clinical diagnostics.

CHANG Medium MF

Constitutional Cytogenetics

Culture solutions designed to support postnatal chromosome analysis in peripheral blood lymphocyte cultures for the evaluation of genetic disease and developmental disorders in adult and pediatric patients.

CHANG™ Marrow is a complete, ready-to-use medium for the culture of human bone marrow cells. Based on IMDM and formulated with a unique blend of growth factors, it is optimized to support superior cell growth and morphology while helping improve the detection of abnormal cells critical to hematologic diagnosis and prognosis.

Increased mitotic index 

Improved morphology 

Fewer culture failures 

Saves time and costs associated with testing 

Reduce Prep. Reduce Variability. Gain Confidence.

Your team’s expertise is too valuable to be spent on routine media preparation. Switching to CHANG™ complete media can help simplify workflow, reduce handling complexity, and minimize variability associated with manual preparation. By lowering operational burden and easing QC demands, laboratories can free skilled staff to focus on high-value cytogenetic analysis.

  • Less preparation time
  • Less handling complexity
  • Less variability from manual mixing
  • More standardized workflow support